ZAP-70 - Concentrate - 0.1 ml

Product Description

Zeta-associated protein-70 (ZAP-70 antibody) is a tyrosine kinase normally expressed by natural killer cells and T cells. Several studies have indicated a correlation between ZAP-70 expression and immunoglobulin heavy-chain variable-region (IgVH) mutational status in the leukemic cells of chronic lymphocytic leukaemia (CLL), with ZAP-70 suggested as a surrogate marker for IgHV mutational status. The mutational status of IgVH genes in CLL is an important prognostic factor in the disease and ZAP-70 overexpression indicates an unfavourable disease course in terms of progression and overall survival.

Specifications:

• Intended Use: IVD
• Species Reactivity: Human, Mouse, Rat
• Source: Mouse Monoclonal
• Clone: BC.2F3.2, Biocare Clone
• Isotype: IgG2a
• Antigen: ZAP-70
• Localisation: Nuclear blush and cytoplasmic
• Positive Control: Tonsil