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RET (10q11.21) Break Apart FISH Probe Orange/Green

SKU:
PBC-PFR7039A

Pack Size: 1

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Product Description

The RET (10q11.21) Break Apart FISH probe is a dual colour probe, designed to detect chromosomal rearrangements involving the RET proto-oncogene (10q11.21). The RET proto-oncogene encodes a tyrosine kinase receptor and under normal conditions, it functions as a signalling molecule involved in cellular growth and differentiation.

Chromosomal rearrangements involving RET were initially identified in papillary thyroid carcinoma1 However, RET gene rearrangements have been identified in Non-Small-Cell Lung Cancer (NSCLC) patients2 RET gene rearrangements in NSCLC result in a novel gene fusion event involving RET and KIF5B gene3 This genetic aberration is believed to play a role in oncogenesis in NSCLC3 RET gene rearrangements can be identified using Fluorescence in situ Hybridization (FISH).

Specifications:

• Intended Use: RUO
• Volume: 100 µl
• Target: Lung
• Colour: Green, Orange
• Chromosome: 10

Additional Information

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