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PD-1 - Concentrate - 1.0 ml

SKU:
PBC-ACI3137CK

Pack Size: 1

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Product Description

Programmed death 1 (PD-1) is a cell surface co-receptor in the CD28/CTLA-4 T cell family and functions as a down regulator of the immune system through a dual mechanism of inhibition. PD-1 is expressed on the cell surface of activated T- and B-cells. Anti-tumour immunity may be controlled by the PD-1/PD-L1 signalling pathway. PD-L1, one of the ligands associated with PD-1, provides immunity for tumour cells by inducing apoptosis of activated T cells or by inhibiting cytotoxic T cells.

Therapies that target the PD-1 receptor have shown unprecedented results with high levels of clinical response in patients with various cancer types. The presence of PD-1 positive tumour-infiltrating lymphocytes (TIL) has been associated with poor prognosis in human breast cancers and may be useful in antibody therapy targeting the PD-1/PD-L1 signalling pathway. Treatments targeting PD-1 and its ligand, PD-L1, have also shown encouraging results in non-small-cell lung cancer, renal cell carcinoma and melanoma.

Specifications:

• Intended Use: IVD
• Format: Concentrate
• Volume: 1.0 ml
• Source: Mouse Monoclonal
• Clone: NAT105
• Isotype: IgG1/kappa
• Antigen: PD-1
• Localisation: Cytoplasmic
• Positive Control: Tonsil

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