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p53 Tumor Suppressor Protein - Predilute - 6.0 ml


Pack Size: 1

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Product Description

p53 has been observed to act as both as a tumour-suppressor and transcription factor. p53 activation by DNA damage or other stress signals is reported to trigger DNA repair, cell-cycle arrest, or apoptosis. The nuclear p53 gene is located on chromosome 17p, a frequent site of allele loss in many tumours (60%) including breast, colon, and lung. p53 Tumour Suppressor Protein antibody mouse monoclonal has also been shown to have prognostic utility for distal colorectal cancer and nasopharyngeal carcinoma by the assessment of mutation and overexpression status.


• Intended Use: IVD
• Species Reactivity: Human
• Source: Mouse Monoclonal
• Clone: DO-7
• Isotype: IgG2b/kappa
• Antigen: p53
• Localisation: Nuclear
• Positive Control: Breast and colon carcinomas

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