MASH1 - Predilute - 6.0 ml

Product Description

Achaete-scute complex homolog-1 (ASCL1), known as mASH1 in rodents and hASH1 in humans, is a basic helix-loop-helix transcription factor that is critical for neuroendocrine cell differentiation. Neuroendocrine carcinomas can arise in different sites such as lung, the gastrointestinal tract, prostate, and skin. High grade, poorly differentiated neuroendocrine carcinomas are classified as neuroendocrine carcinomas (NECs) and are distinguished from low grade neuroendocrine tumours (NETs). Classic neuroendocrine markers such as chromogranin and CD56 cannot distinguish NECs from NETs. Studies have shown that the mouse monoclonal antibody MASH1 [24B72D11.1] stains hASH1 in human tissues and can distinguish NECs from NETs in various sites. MASH1 has also been shown to distinguish large cell neuroendocrine carcinomas (LCNECs) and small cell lung carcinomas (SCLCs) from other phenotypes of lung cancer. MASH1 has also been used to differentiate SCLC from Merkel cell carcinoma. While not a tissue-specific marker, MASH1 may assist in distinguishing neuroendocrine carcinomas from neuroendocrine tumours in poorly differentiated cases.

Specifications:

• Intended Use: IVD
• Format: Predilute
• Volume: 6.0 ml
• Source: Mouse Monoclonal
• Clone: 24B72D11.1
• Isotype: IgG1
• Antigen: Achaete-scute complex homolog-1
• Localisation: Nuclear
• Positive Control: Neuroendocrine tumour
• Species Reactivity: Human, Others Not Tested