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IMP3 (RM) - Predilute - 6.0 ml


Pack Size: 1

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Product Description

IMP3 (insulin-like growth factor II mRNA-binding protein 3) is a 580 amino acid oncofetal RNA binding protein containing four K homology domains which is encoded by a 4350 bp mRNA transcript produced by the IGF2BP3 gene on chromosome 7p11.5 (1,2). Its relevance as a novel biomarker in many kinds of cancer has been recently published and data also suggest that IMP3 may play an important role in malignant transformation (3). Cytoplasmic expression of IMP3 has been associated with a more aggressive phenotype in many cancers including triple negative (basal-like) breast cancers, colon cancers, lung cancer and prostate cancer (4-7). IMP3 has also been used in discriminating between benign vs malignant cancers and IMP3 has been shown to be a marker of high-grade dysplasia in oesophageal adenocarcinoma (3, 8-10).


• Clone: EP286
• Format: Concentrate, Predilute
• Intended Use: IVD
• Isotype: IgG
• Localization: Cytoplasmic / nuclear
• Source: Rabbit Monoclonal
• Volume: 0.1 ml, 0.5 ml, 6.0 ml
• Species Reactivity: Human; others not tested

Additional Information

Additional information is not currently available.


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