HPV Cocktail Broad Spectrum - Concentrate - 1.0 ml

Product Description

The broad spectrum HPV antibody was produced (1H8) against SDS-disrupted bovine papillomavirus type 1 (BPV-1) and used to identify the product of the L1 open reading frame (ORF) of BPV-1. IH8 was found to be reactive with purified major capsid protein (MCP). The antibody was tested with ELISA and with an immunofluorescent technique and detected HPV-1, 6, 11, 16, 18, and 31 in formalin-fixed paraffin embedded biopsy specimens. The CAMVIR-1 antibody was raised against the major capsid protein L1 of human papillomavirus type 16, using a recombinant vaccinia virus that expresses the L1 protein, as a target for screening. This antibody reacted with a 56 kilodalton protein in cells infected with L1-vaccinia virus, and the protein was present in HPV16. A panel of p16 and Ki-67 can be used for further evaluation. CAMVIR-1 may also be used separately for phenotyping HPV-16. Other HPV isotypes may also be reactive with the Broad Spectrum HPV antibody, but have not been tested.

Specifications:

• Intended Use: RUO
• Species Reactivity: Human
• Source: Mouse Monoclonal
• Clone: BPV-1/1H8 + CAMVIR-1
• Isotype: IgG + IgG2a
• Antigen: HPV Cocktail Broad Spectrum (HPV-1, 6, 11, 16-16, 18 and 31)
• Localization: Nuclear
• Positive Control: Infected cervical biopsy