H3K27me3 [C36B11] - Concentrate - 1.0 ml

Product Description

H3K27me3 (histone 3 lysine 27 trimethylation) is an epigenetic mark that plays a critical role in regulation of gene expression. The dysregulation of H3K27me3 is implicated in the genesis and progression of cancer. Studies indicate that H3K27me3 plays a role in the creation and maintenance of cell type-specific programs of transcriptional control for a wide variety of species and cell fates.1 H3K27me3 expression was shown to be a significant prognostic indicator in breast, ovarian and pancreatic cancers. Low expression of H3K27me3 correlated with significantly shorter overall survival time compared to individuals with high H3K27me3 expression.2 H3K27me3 may be a useful marker in diagnosing malignant peripheral nerve sheath tumours (MPNSTs) and providing molecular insight in progression of prostate cancer.3,4

Specifications:

• Intended Use: IVD
• Format: Concentrate, Predilute
• Volume: 0.1 ml, 1.0 ml, 6.0 ml
• Species Reactivity: Human; others not tested
• Source: Rabbit Monoclonal
• Clone: C36B11
• Isotype: IgG
• Antigen: H3K27me3
• Localization: Nuclear