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E-Cadherin [CDH1/2208R] - Concentrate - 1.0 ml

SKU:
PBC-ACI3230C

Pack Size: 1

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Product Description

E-Cadherin is a transmembrane glycoprotein that plays a key role in cell adhesion in epithelial tissues (1-2). The adherens junction between epithelial cells is comprised of extracellular domains of E-Cadherin from adjacent cells, which interact through a molecular zipper motif. In normal tissues, immunostaining of E-Cadherin is localized to the membrane of epithelial cells, consistent with its role in cell adhesion. Immunohistochemical studies have shown E-Cadherin to be expressed in breast ductal carcinoma with loss of expression in lobular carcinoma (1-2). As a result, mouse monoclonal anti-E-Cadherin [HECD-1 has been used by pathologists to differentiate between ductal and lobular carcinomas of the breast, with currently published sensitivity and specificity of approximately 90% (3). Rabbit monoclonal E-Cadherin antibody may combine the best properties of both monoclonal antibodies and rabbit antisera.

Specifications:

• Intended Use: IVD
• Format: Concentrate, Predilute
• Volume: 0.1 ml, 0.5 ml, 6.0 ml
• Species Reactivity: Human; others not tested
• Source: Rabbit Monoclonal
• Clone: CDH1/2208R
• Isotype: IgG
• Antigen: Recombinant full-length human E-Cadherin protein
• Positive Control: Normal breast or breast ductal cell carcinoma

Additional Information

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