CD103 (RM) - Concentrate - 0.1 ml

Product Description

CD103 antibody recognizes the integrin subunit CD103 cell surface antigen, which is characteristically expressed in hairy cell leukaemia (HCL), a B-cell lymphoproliferative disorder (1-3). CD103 [EP206] has demonstrated reactivity in FFPE (formalin-fixed paraffin-embedded) tissue, eliminating the need for flow cytometric analysis or frozen section IHC, making it a valuable addition to an immunohistochemistry (IHC) panel for the diagnosis of HCL (1). Other antibodies that have been used in conjunction with CD103 for the detection of HCL include CD25, TIA-1, DBA44 and CD11c (2-3). Intraepithelial CD8 (+) tumour-infiltrating lymphocytes (TIL) that express CD103 have been shown to be strongly associated with patient survival in high-grade serous ovarian cancer (HGSC) (4).

Specifications:

• Intended Use: IVD
• Format: Concentrate, Predilute
• Volume: 0.1 ml, 0.5 ml, 6.0 ml
• Source: Rabbit Monoclonal
• Clone: EP206
• Isotype: IgG
• Antigen: A synthetic peptide corresponding to the residues of human CD103 protein
• Localization: Cell Membrane
• Positive Control: Hairy cell leukaemia