BRAF V600E [VE1] - Ultraline - 6.0ml

Product Description

BRAF, a serine-threonine protein kinase, is a member of the RAF kinase family and plays an important role in the RAS-RAF-MAPK signalling pathway, which regulates cell survival, proliferation, and differentiation. Mutations in BRAF results in pathway alteration and sustained kinase activity which lead to carcinogenesis. The bulk of these mutations occur when an amino acid sequence is mutated which leads to valine (V) being substituted for glutamate (E) at codon 600 (V600E). BRAF V600E mutation has been established in various types of cancers, such as melanoma, papillary thyroid carcinoma, and metastatic colorectal adenocarcinoma with a frequency of mutation at about 50%, 45%, and 9%, respectively. Previous studies have shown that the prevalence of BRAF mutation in lung carcinoma is approximately 2-4%.

Specifications:

• Intended Use: IVD
• Format: UltraLine
• Volume: 6.0 ml
• Clone: VE1
• Source: Mouse Monoclonal
• Species Reactivity: Human; others not tested
• Isotype: IgG2b
• Localisation: Cystoplasmic