Bcl-6 [LN22] - Predilute - 6.0 ml

Product Description

BCL-6 Mouse Monoclonal Antibody is commonly expressed in diffuse large cell lymphomas, follicular lymphomas and Burkitt’s lymphoma/leukaemia. Bcl-6 protein is expressed mainly by follicle centre cells, a few interfollicular T lymphocytes and in nodular lymphocyte predominant Hodgkin’s disease. However Blc-6 mouse monoclonal is not expressed in hairy cell leukaemia, mantle cell or marginal-zone derived lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal centre formation. The LN22 clone of Bcl-6 provides superior sensitivity compared to [PIF6].

The Bcl-6 gene, originally cloned from a tumour with 3q27 translocation, is commonly expressed in large cell lymphomas. In humans, Bcl-6 encodes for a Kruppel-type zinc finger protein that is believed to be important in germinal centre formation.

Specifications:

• Intended Use: IVD
• Source: Mouse Monoclonal
• Clone: LN22
• Isotype: IgG2b
• Antigen: AA 1-350 N-terminus human Bcl-6 oncoprotein
• Localization: Nuclear
• Positive Control: Tonsil or Follicular Lymphoma