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Bcl-2 - Concentrate - 1.0 ml

SKU:
PBC-CM003C

Pack Size: 1

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Product Description

The 100/D5 antibody is highly specific to the Bcl-2 antibody (alpha) and shows no cross-reactivity with Bcl-x or Bax protein.

Bcl-2 (b-cell lymphoma #2) is a proto-oncogene located at 18q21.3. The expression of Bcl-2 alpha oncoprotein has been shown to inhibit apoptosis. In most follicular lymphomas, neoplastic germinal centres express high levels of Bcl-2 protein, whereas the normal or hyperplastic germinal centres are negative.

Various B- and T-cell lymphoproliferative diseases and some diffuse large B-cell lymphomas are Bcl-2 positive while Burkitt’s lymphoma/leukaemia is generally negative.

Specifications:

• Intended Use: IVD
• Source: Mouse Monoclonal
• Clone: 100/D5
• Isotype: IgG1/kappa
• Antigen: bcl-2a
• Localization: Cytoplasmic and nuclear membrane
• Positive Control: Follicular lymphomas or tonsil

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